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Fat and appetite suppression

A high fat meal reduces hunger while in the small intestine, not the stomach. This is induced via CCK (cholecystokinin), a gut hormone involved in appetite signaling. Delaying the digestion of dietary fat elevates CCK further and results in higher…

Intramuscular fat stores and athletic endurance

Intramuscular fat, stored in each muscle cell, is depleted with endurance exercise, just as glycogen is. This fat can only be replenished quickly if fat is consumed. If intramuscular fat is not replenished, fat oxidation rates remain unchanged, but the…

Metabolic sensing neurons and obesity

Metabolic sensing neurons integrate a variety of signals and respond to glucose levels, fatty acids, insulin, leptin and other hormones and their metabolites. The brain uses this data to control appetite and food intake. Some obese people experience a genetically…